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large Blue continues to weather industry storms and are available out on correct. 

by way of John Russell

Sept. 5, 2008 | attempting to describe in a single story the whole scope of IBM’s lifestyles Sciences and Healthcare activities and related work being accomplished via IBM analysis is at most appropriate formidable and at worst foolhardy. massive Blue may well be entertaining in the corporate world when it comes to the sheer quantity, diversity, and depth of its actions.

IBM revenues will desirable $100 billion this 12 months, with functions accounting for more than half ($54 billion in ’07). despite the fact the Americas still make up the largest piece of the pie, Asia/Pacific, Europe, core East, and Africa jointly make contributions basically 60% of revenues. Headcount is around 388,000, with all of a sudden transforming into encampments in India (ninety four,000 through year’s conclusion) and China (already IBM’s international procurement headquarters). through most measures—profits, money, salary per share, margins, and many others.—IBM is in remarkable health despite the macro financial malaise in Europe and North the united states and volatility within the IT sector.

Likewise, IBM analysis is in exceptional fettle. The Thomas J. Watson research core in Yorktown Heights, the big apple, remains the surprising centerpiece, but is joined via seven amenities around the globe in Zurich, Beijing, Almaden (CA), Austin (TX), Haifa, Delhi, and Tokyo. The business continues to spew out patents, 35,000-plus and growing.

Of direction Blue Gene—IBM’s line of supercomputers named for grand challenges in biology—dominates the excellent 500 lists. The variety of IBM scientists is inconspicuous, 3200, however wide collaboration with scientists, academics, governments, and different businesses worldwide radically enlarges their footprint and have an effect on. here are only just a few ongoing IBM research projects primary to the fitness care and biomedical analysis:

STEM—The Spatiotemporal Epidemiological Modeler is an advanced tool to help medical and government executives determine, music, and probably predict the course of infectious disease outbreaks. It’s now administered by using the open supply ECLIPSE firm. The underlying know-how will likely locate plenty of makes use of.

Checkmate—along side Scripps Institute, Checkmate aims to stronger keep in mind and simulate viral mutations—akin to chicken flu—to boost constructive manage and containment measures. Blue Gene-scale computing, new algorithms, and advanced microfluidics are all associated with this undertaking.

Pyknons (Greek adjective for dense)—IBM computational biologist Isidore Rigoutsos is uncovering new functions for “junk DNA.” He makes use of term Pyknons for the tremendous variety of non-coding DNA motifs identified through his pattern recognition thoughts, which may additionally have crucial regulatory roles.

Blue brain—the use of the computational skill of IBM’s eServer Blue Gene, researchers from IBM and Ecole Polytechnique Fédérale (Switzerland) are developing an in depth circuit mannequin of the neocortex—the largest and most complex a part of the brain.

The Genographic task—IBM is contributing funding, science, and computational support to study ancestry of indigenous populations and volunteers (see, “international Blue Genes”).

here is only the glistening tip of massive Blue’s research berg. an enormous array of other projects, well-nigh all of them undertaken with paying companions, hum away below the surface, tackling essential life sciences questions whose options also present concrete commercial opportunities for IBM.

Yet these days’s graphic of cooperate robustness and analysis energy became much unsure 15 years in the past and is a testomony to IBM’s ruthless and critical re-invention. in the early 90’s, with giant amounts of purple ink flowing, many notion IBM’s choicest days were in the back of it. every so often background can be instructive.

overseas Blue Genes

a couple of years in the past, IBM raised eyebrows by way of partnering with the national Geographic Society to launch the Genographic venture (see, “Taking a global Genography verify,” Bio•IT World, June 2005). Scientists scoured the globe to collect DNA samples from indigenous populations. in the meantime, the conventional public may (and still can) purchase $ninety nine DNA kits, permitting them to put up a cheek swab and study their family unit’s ancestry by means of the genotyping of the (paternally inherited) Y chromosome, or the maternally transmitted mitochondrial DNA. 

Ajay Royyuru, analysis scientist and senior manager, Computational Biology middle, leads IBM’s contribution to the primary posted statistics from the Genographic project. Two such examples have been published in the American Journal of Human Genetics final spring.

in one analyze, IBM and the Genographic mission group collaborated with Lebanese American tuition researchers in Beirut to genotype Y chromosomes from greater than 900 Lebanese volunteers. each individual supplemented their genetic records with very own advice together with their self-described ethnicity and faith. “It isn't seen as an intrusive query in that part of the realm,” Royyuru says wryly.

The researchers compared the Y genotypes of the three foremost ethnic businesses in Beirut—Christians, Druze and Muslims. some of the main conclusions was that religious affiliation has a great impact on patterns of genetic adaptation within the three ethnic populations in Lebanon than say geographic variations. but Royyuru notes that there isn't “one genotype that's unique for any spiritual affiliation. All of those spiritual labels are from the ultimate few thousand years. The genetic labels are tens of lots of years ancient.”

however the genetic evaluation provides compelling facts of old migrations to Lebanon. About 250,000 men are estimated to have reached Lebanon from Europe during the Crusades. A Y-chromosome haplotype known as WES1 (a subtype of the most ordinary western European haplotype R1b) gives mighty facts for the Christian migration all over the Crusades. WES1 is found in 0.2% of European populations east of Hungary, yet bills for 2% of the R1b haplotypes in Lebanese Christians. And yet it's completely absent in a database of greater than 1,000 core-japanese Y chromosome haplotypes. an analogous fashion is viewed for an extra haplotype spreading from the Arabian peninsula into the Lebanese Muslim inhabitants.

A 2d study checked out mitochondrial DNA diversity, and concludes that the African Khoisan population diverged from the rest of the human mtDNA pool ninety-a hundred and fifty,000 years ago. extra lineages merged with the Khoisan within the late Stone Age, about forty,000 years in the past.

Royyuru says the Genographic undertaking continues to adapt, but the focal point continues to be on knowing deep ancestry. Proceeds from the DNA kits—greater than 250,000 sold to this point— are assisting a few dozen legacy projects providing can provide for indigenous populations. -- Kevin Davies

Getting it RightMichael Hehenberger, international solutions govt for all times sciences/pharma, joined IBM in 1985. “In 1989, I grew to be the international opportunity supervisor for chemical/pharmaceutical R&D out of Paris, as a result of this was an industry the place Europe become very strong. I need to admit they failed in making a sustained IBM enterprise, but I additionally suppose they approached the challenge in the wrong method: i used to be given a lot of elements, however i used to be additionally given a constraint. You have to do every little thing to run R&D options on the mainframe.” Hehenberger believes IBM is getting it right this time.

The wrenching adjustments of the early ’90s initiated a change that continues internal IBM. Over time, the “product” mentality has been supplanted via a options and service mantra that emphasizes higher-cost choices and led to the jettisoning of its notebook enterprise. Its go-it-on my own method has morphed into a can’t-do-it-alone consciousness (60 acquisitions in five years) this is far more accommodating to companions and embracing of open supply. clients also stressed out they didn’t care about know-how (or company) per se, however panic noticeably about fixing specific complications, correctly and less expensively.

“We’ve discovered plenty because 1993 via their own adventure,” says Michael Svinte, VP world pharma/lifestyles sciences and an IBM veteran. “We’ve lived via a lot of complexity and alter and transformation. Their consumers in pharma 5 or ten years ago didn’t need to hear about that. It didn’t suggest anything else to them because it become respectable business, the Halcyon days of pharma. Now their challenge is different and their journey is a big abilities in having these conversations.”

IBM weathered the storm and remade itself. while it isn’t a company or place of work nirvana, it is again bright, prosperous, and tackling eye-popping tasks that few competitors may take into account.

indeed, now that health care and existence science has emerged as an enormous chance, IBM executives feel they could argue that big Blue has something effective to say—not just promote—to giant biopharma corporations whose plight (patent expiry, hovering R&D prices) resembles IBM’s waning huge Iron days. foremost consulting acquisitions comparable to Healthlink and PricewaterhouseCoopers (consulting) have bolstered that argument via including indispensable business advantage (plus shoppers) to fit IBM’s extensive expertise capacity.

IBM TodaySo what is IBM up to these days within the lifestyles sciences and fitness care communities—an international whose boundaries IBM thinks are blurry at top-quality—and how does its most beneficial analysis corporation healthy into this graphic?

“we now have a lot of supplies,” says Svinte. “Our challenge is to choose areas that they in reality wish to go after. they have finished that within the life sciences area.” Svinte cites IBM’s biennial global CEO survey as an invaluable aid in choosing key areas (see, “IBM CEO Survey shows starvation for exchange in existence Sciences”).

aside from for a moment IBM research exotica—and even exotica ought to raise its personal water these days—IBM has divided the health care and existence sciences area into three objectives: lifestyles Sciences/Pharma; issuer (fitness care birth); and fitness Plan/Payer. inside each bucket, IBM sets a “method center of attention” from which flows productized solutions.

as an example, the approach in existence Sciences/Pharma is to assault in three areas—R&D productivity, regulatory compliance, and operational effectivity—and carry solutions aligned for every approach bullet. an excellent instance is IBM’s ranking—solution for Compliance in a Regulated environment.

document management is certainly a big a part of it, with all the bells and whistles you’d are expecting from IBM and which are required by means of FDA. but potent graphic administration capability is additionally part of ranking as is “song & music” performance which can be used to monitor and comfortable deliver chains. A ordinary theme is co-construction of these options with predominant purchasers. in reality, IBM has a ranking-Bio-clinical Imaging answer that fell out of a collaboration with Merck.

“in one huge medical trial, the place imaging become an immense element, simply the [Merck] funds for mailing and postage and coping with became more than $5 million,” says Hehenberger. “we can manage all types of documents. They also had a solution coming out of IBM research the place they had a method of managing bio-medical imaging information. So they mixed that with their ranking answer and they had what Merck required.”

Of direction, IBM also has move-segment infrastructure options (utility, hardware, middleware, services) upon which to run segment particular applications.

additionally in the biopharma business, IBM has generally identified alternatives in biomarker (imaging and omic) management, in silico R&D, statistics integration, and regulatory compliance. Imaging is a very sizzling enviornment.

The IBM Healthcare and life Sciences company geared up four Biobank Summits and 4 Imaging Biomarker Summits, led by way of Hehenberger, as part of its more collaborative approach to enhance options to industry issues and products IBM can sell. These meetings drew attendees from FDA, tremendous pharma, and expertise carriers together with GE, Siemens, and Philips.

Hehenberger says drug approval is often delayed—even prevented—as a result of inadequate imaging guidance.  now and again he says, pictures had been amassed however can not be found.

Avastin and ImClone’s Erbitux are noted situations, he says. “[ImClone] couldn’t convince the FDA as a result of they didn’t locate the statistics. It changed into an excellent drug. I mean they may also have made some mistakes additionally in their design of the medical trials, however imaging was a vital factor. It’s crucial that the image nice [and] then the administration of the images [be handled effectively] in a regulated atmosphere.”

huge Blue expects the boom in imaging for diagnostics and drug development to drive a major market for expertise enablers. at first, it has suggested clear of PACS imitation, focusing as an alternative on clinical trials, and is even Preparing a hosted carrier, which will control photos for scientific trial sponsors. As is increasingly typical, components of the answer came from IBM’s IT infrastructure portfolio, half from IBM analysis efforts, and extensive customer involvement.

“I’m not asserting they have solved the entire problems,” says Hehenberger. “There’s a challenge of making issues handy to make use of, of no longer deviating too a good deal from the environment they’re used to, however still sending those photos to the CRO and then to the pharmaceutical company. This allows the imaging department and different investigators to look at the photographs and video display what’s going on. There’s lots of communique happening and people are massive data, so, it’s very worrying for the IT infrastructure.”

“we now have [also] diagnosed the value of modeling and simulation and we’re going to do what they did for imaging biomarkers.” His neighborhood is planning conferences in Japan and manhattan via 12 months’s conclusion.

things have modified on account that 1989, when Hehenberger’s precedence in selling to pharma turned into to make Macs and PCs behave as dumb terminals to preserve the role of mainframes and their applications. “I’m very happy for this 2d chance,” he says, his exuberance tempered by way of previous realities and seems to be shared with the aid of nowadays IBMers. They don’t forget the struggle.

a further exciting providing is IBM’s Unstructured assistance management and Mining answer (UIM). “we now have now 4 implementations within the business of what they name business intelligence workbench. The thought is to combine sources of unstructured information and to annotate them and, once again, have an open architecture. So, where they don’t have the most desirable algorithm ourselves, they can in reality import outdoor concepts and algorithms for annotation. that you may study chemicals, biomarkers, genes, proteins, illnesses, signs, and so on.,” says Hehenberger.

IBM Healthcare and existence Sciences’ portfolio is extensive, effective, and to a considerable diploma, customer and partner driven. as an example, IBM and Oracle jointly present the lifestyles Sciences Hub, a platform and suite of purposes to manage scientific trial and different biomedical information.

Svinte notes IBM options may still assist force enterprise innovation. So as an example, rating shouldn’t just keep a corporation in compliance but additionally supply intelligence vital to inform an organization’s strategy.

features are a huge piece of Healthcare and life Science’s business. these days, as an instance, IBM prolonged its contract with AstraZeneca to manage its IT infrastructure. the new deal is for $1.4B over seven years; materials of the brand new collaboration lengthen to analysis, now not simply IT.

“IBM is partnering with AstraZeneca, Karolinska Institute (KI), and different educational institutions in the Stockholm mind Institute (SBI), an instance of a public/deepest partnership. The emergence of such PPP’s is a strong international fashion. SBI’s research is focused on the fundamental understanding of cognition and learning. Cognitive dysfunction is the reason behind many vital illnesses corresponding to Alzheimer’s, Parkinson’s, ADHD, Schizophrenia, and many others.,” says Hehenberger.

“apart from the evaluation of molecular and scientific records, purposeful MRI and PET (by means of Siemens’ HRRT instrument with the trade’s maximum feasible resolution) imaging reviews, SBI is the use of desktop simulations based on IBM’s Blue Gene platform. The aim is to get an realizing of neuroscience sickness mechanisms and to locate new biomarkers. The SBI wants to get analysis consequences that will also be used to boost new medical remedies and may be translated into improvement, eventually, for the patient.” he says.

Svinte says the latitude and scope of IBM features continues expanding. as an example, IBM has for some time provided supply chain administration and procurement functions. in spite of everything, IBM’s subculture and mandates are such now that his corporation can deliver all internal events—features, products, IBM research—to bear on customer engagements.

research RoleOver $30B has been spent to fund IBM R&D during the past five years. no doubt massive chunks go to guide the nuts and bolts of infrastructure hardware and utility construction.

but here's additionally the land of Blue Gene, the place computational brawn and magnificence are mixed to handle massive and tiny problems. It’s additionally Ajay Royyuru’s office (and toy container).

Royyuru is the senior supervisor of IBM analysis’s Computational Biology center (CBC) at Watson analysis center. (See columnist Michael Greeley’s article, “What’s New at large Blue,” Bio•IT World, March 2005) He leads 35 researchers digging into tasks covering bioinformatics, structural biology, purposeful genomics, techniques biology, and medical informatics. Royyuru is himself the lead scientist for IBM on the Genographic undertaking.

His working towards includes a grasp’s degree in biophysics, a Ph.D. in molecular biology in India, and postdoctoral analyze in structural biology at Memorial Sloan-Kettering melanoma center, offering a step forward animal mannequin for HIV analysis. prior to becoming a member of IBM research in 1998, Royyuru spent two years establishing structural biology utility at Accelrys.

IBM’s CBC covers a really remarkable array of analysis projects, from mining and modeling of biological networks (Gustavo Stolovitzky) to structural reports of rhodopsin and its strategies of activation (Mike Pitman); and from excessive-efficiency computing for scientific imaging and neuroscience (Charles Peck) to genetic regulatory motifs (Isidore Rigoutsos).

although lots of this sounds very tutorial, the entire work is embedded in IBM’s options-for-true-problems approach. Many tasks are delivered to IBM by means of clients who pay to place big Blue to work. As outlined with the aid of Joseph Jasinski, IBM special engineer and software director, Healthcare & existence Sciences, the research effort has 5 strategic focuses:

  • increase effectiveness, safety, and cost of clinical care and public health via greater analysis, medication, and operational effectivity
  • enrich operational efficiency and consumer relationship capabilities of health care payers and patrons
  • increase new, extra effective, medicine faster and more cost-effective
  • Translate molecular biology research into scientific care
  • bear in mind biological techniques with predictive fashions
  • “The IBM research enterprise model has modified dramatically,” says Jasinski. “eighty% of the work [Ajay’s] computational biology core does is with consumers and collaborators. Why does he do this? now not to work on today’s issues, however [to identify] the massive rising challenges on a three-to–5 year horizon…  this is such an enormous abilities to what they do and what they are able to present to their purchasers.”

    Some exceptional science is being performed as neatly. Isidore Rigoutsos, manager, Bioinformatics and demo Discovery, is main a computational effort to investigate non-coding (junk) DNA. His work suggests there are a major variety of conserved intronic sequences called pyknons that have regulatory roles. additionally, while they cluster in similar functional areas across organisms, they are inclined to have distinctive exact sequences.

    Such insights might have profound affect on understanding animal fashions of ailment and perhaps explain why they are often bad predictors of human response. His work has identified pyknons implicated in colon cancer. And the clever demo consciousness algorithms and recommendations he has developed are likely finally to be embedded in tools.

    Gustavo Stolovitzky, manager, useful genomics & methods biology, has multiple research interests. Some efforts—his work with the DREAM project (dialogue on Reverse Engineering assessment and techniques) and coronary heart modeling and simulation—are relatively visible. other projects are nevertheless mostly personal however tantalizing, corresponding to some pleasing preliminary work on nanopore DNA sequencing.

    There are probably many proprietary courses saved under the shut eye of sponsoring valued clientele. this is a part of the brand new IBM research mission. Curiosity on my own is frequently no longer adequate.

    Compute ChampApart from the human brain energy, the other jewel in IBM research is Blue Gene, or rather the family unit of Blue Gene supercomputers, introduced in 1999, and whose predecessor Deep Blue defeated chess legend Garry Kasparov in 1997. Blue Gene/L debuted in 2004 and grew in performance to the lots of of teraflops. here's the version that the IBM CBC used.

    Yet simply down the hall within the Watson Lab is a Blue Gene/P, which when utterly provisioned with 256 racks, will obtain three.56 petaflops. This latest computational beast has had practically everything optimized—cabling, cooling, power, etc,—and will allow organic simulations on a tons faster and deeper scale. Of direction, the line received’t stop there. Plans demand a one hundred-petaflop Blue Gene/Q to debut around 2010.

    clearly not everyone can manage to pay for (or has the potential to run) any such behemoth. IBM says the trouble required to application Blue Gene has been vastly simplified, and it even sells entry to Blue Gene as an “on demand” service to shoppers equivalent to Gene network Sciences.

    certainly IBM has come a protracted way. The chastened giant stumbled but found the grit to exchange and regain its stride in what is arguably a more difficult, coarser, less forgiving enterprise environment. Says Svinte: “IBM’s strategy, no longer just Healthcare and life Sciences, has three planks—open technologies and excessive price solutions; integration innovation; and becoming a premier world built-in business. That’s driving all of their initiatives.”   

     IBM CEO Survey suggests starvation for trade in life Sciences

    “exchange” isn't purely a common chorus on the presidential election campaign path. It’s additionally what dozens of existence science CEOs are hankering for, in line with preliminary findings from the latest IBM CEO survey.

    Michael Svinte shared a few of those findings with Bio•IT World at a briefing during the Drug business affiliation convention (DIA) this June in Boston.

    each two years, IBM conducts a comprehensive CEO look at, surveying hundreds of trade chief executives. For the 2008 survey, IBM spoke with 1,a hundred thirty CEOs, including 40 in the life sciences and pharma enviornment. (Eight of the CEOs got here from the Americas, 46 p.c from Europe/middle East/Africa and 34 percent from Asia-Pacific.)

    Svinte says the outcomes, that have been published in a full white paper, are essential in permitting IBM to allocate its supplies into acceptable areas of need.

    there have been 5 predominant takeaways from the lifestyles science CEO responses, in accordance with Svinte. Chief among them changed into a hunger for change. seventy nine % of the lifestyles science CEOs anticipated most important exchange in the next few years. skill concerns, regulatory issues, and market elements were probably the most often referred to elements.

    but 25 p.c of the CEOs polled said they were struggling to manage exchange inside their corporations. One American huge pharma CEO referred to, “We recognize they need to trade faster, however are they adaptive enough? there is lots of skepticism internally with regard to their change capabilities.”

    The other key training Svinte and colleagues extracted from the survey include:

    • Innovation beyond consumer creativeness: CEOs were “bullish” about the enhance in purchaser buying vigour. “patients may be more concerned as a result of they’re more advantageous counseled,” noted one European pharma CEO. The survey showed investment during this area projected to grow by using 43 p.c within the coming years, but less for extra refined buyers. Svinte says life science groups face an important challenge “enticing the broader ecosystem,” (akin to IBM’s evolution in accurate years), as they pursue new markets, new business operations, and new operations.

    • international integration: ninety % of life science CEOs wondered are coming into new markets, however they are wary of legislative regulation and highbrow property considerations. As with the larger examine, insufficient talent is a serious obstacle, they noted.

    • business model innovation: Three quarters of the lifestyles science CEOs are pursuing “extensive business model innovation over the next three years.” here, the emphasis among the many CEOs is on enterprise model innovation. “Our future is in convergent technologies, where they mix distinctive elements of their company with know-how, for instance, combining a technological element with medicine,” referred to one European pharma CEO. surprisingly perhaps, fewer than 20 p.c of the CEOs are enjoyable trade mannequin innovation. IBM expects to look merging capabilities among pharma, fitness care and diagnostic organizations as new business models emerge.

    • Social accountability: sixty two percent of life science CEOs reacted favorably to exhibiting social accountability. This essentially impacts the manufacturing space and scientific through-items, yet one quarter of CEOs doubted that better social responsibility would boost their enterprise.  -- Kevin Davies


    this article appeared in Bio-IT World magazine.

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