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Evogene: Q3 replace And Upcoming Catalysts | 156-115.77 Cheatsheet and Dumps

Headquartered in Israel and with workplaces in the U.S., Evogene Ltd. (EVGN), (TASE: EVGN), has developed a number one-side computational predictive biology platform ("CPB Platform") developing next-era existence sciences products with novel modes of moves, starting from seeds, to microbiome therapeutics, herbicides, pesticides and medical cannabis.

Evogene's 4 main subsidiaries make the most of Evogene's CPB Platform. In August and September, I posted a four part series of articles on Evogene (EVGN). each of my four articles focused on one Evogene subsidiary.

The articles may also be discovered at:

Evogene: Hidden gems Of Computational Predictive Biology, part 1 Of 4 (Biomica, Microbiome Therapeutics)

Evogene: Hidden gemstones Of Computational Predictive Biology, half 2 Of four - Lavie Bio

Evogene: Hidden gems Of Computational Predictive Biology (part three Of four) - Ag Plenus (Novel Herbicides And Pesticides)

Evogene: Hidden gem stones Of Computational Predictive Biology: (part four Of 4), Canonic Ltd. (clinical hashish)

All figures referenced in this article are in $USD.


On September 1, Evogene announced that ARK invest (via ARK Genomic Revolution Multi-Sector ETF (ARKG)), had made a $7 million investment in Evogene (at $1.70 per share), as a part of a $10 million deepest placement. ARK invest is a number one ETF fund based in manhattan led by Catherine timber. The ARK family unit of ETF cash invests in disruptive applied sciences (via investments in public groups).

On November 4, Evogene announced the closing of an further $12 million financing "with an existing institutional shareholder and likely Israeli institutional investors providing for the issuance of an mixture of (1) 3.92 million regular shares at a purchase cost of $2.50 per share, and (2) 883,534 pre-funded warrants each and every to buy one usual share (“Pre-Funded Warrants”). The Pre-Funded Warrants had been sold at a cost of $2.49 each, with an pastime rate of $0.01 per commonplace share. ... "

ARK Genomic Revolution Multi-Sector ETF (ARKG) is Evogene's biggest shareholder possessing approximately 12% of Evogene's outstanding shares.

Evogene's Q3 2020 fiscal effects and conference name

On November 18, 2020 Evogene launched its Q3 2020 economic outcomes and corporate update, adopted that morning with a 1-hour conference call. A looking for Alpha transcript of the name may also be found right here.

company summary as of November 27, 2020

(All greenback figures are $USD)

Evogene usual shares exchange below the image 'EVGN' on each the NASDAQ and Tel Aviv inventory alternate. All references to Evogene shares in this article are to NASDAQ listed shares in $USD.

Shares unbelievable - 35,574,954 commonplace shares (or 36,458,488 normal shares together with the entire pre-funded warrants). The aforementioned figures received from Evogene's October 30, 2020 prospectus.

Share cost at the shut of November 27, 2020: $2.93

52-week share finances: $0.75 to $5.30

latest Market Cap: Approx. $one hundred and five million

Debt: no debt other than regular payables

money or equal: approximately $50 million (my estimate based upon $forty three.5 million cash/equivalents as of September 30, 2020 financial statement, plus further $12 million deepest placement announced closed on November 4, 2020, less estimated burn price). The $50 million includes about $13 million money held in Egovene's 72s% owned subsidiary Lavie Bio.

in accordance with its Q3 monetary consequences filed November 18 with the SEC, right through the 9-month period January 1 to September 30, 2020, Evogene's consolidated net money utilization become $13.four million (or $9.3 million with the exception of Lavie Bio's money utilization). during Q3 2020, Evogene's consolidated net money utilization turned into $four.6 million (or $3 million excluding Lavie Bio's cash utilization).

Evogene's Computational Predictive Biology "CPB" Platform

Evogene claims that its CPB Platform offers it with a competitive facet to greatly increase the probability of a hit life-science product development, boost the efficacy, and in the reduction of the toxicity of its life-science items whereas reducing time and value to development.

Its strategic partners encompass important multinational corporations equivalent to BASF (OTCQX:BASFY), Bayer (OTCPK: BAYZF), Corteva (CTVA), as well as principal regional organizations akin to Israel-based mostly ICL community Ltd. (ICL), and quite a lot of academic and clinical associations.

As of June 30, 2020, Evogene has 121 personnel (including its subsidiaries), together with 40 with Ph.D. levels, with multidisciplinary and wide-ranging potential in biology, chemistry, genetics, agronomics, mathematics, computer science, and different related fields.

internal Ag-seed trait division and its 4 leading Subsidiaries (Biomica, Lavie Bio, AgPlenus, and Canonic)

besides Evogene's internally owned Ag-seed trait division, it has 5 subsidiaries of which four are huge, together with Biomica, Lavie Bio, Ag Plenus and Canonic.

this text gives an replace on the 4 main subsidiaries and upcoming catalysts.

1. Biomica Ltd.

90% Owned subsidiary Biomica Ltd. focuses on microbiome-based mostly therapeutics for the treatment of immune-mediated and infectious illnesses.

For some extra background on the science at the back of the connection between the intestine microbiome and melanoma, i like to recommend analyzing "Can patients intestine Microbes support fight cancer" published November 20, 2020 in Science magazine online.

There has additionally been a lot of excitement this 12 months in the microbiome therapeutics house as very effective medical data has been rising, demonstrating the knowledge colossal price of the microbiome therapeutic strategy.

as an example, in August of this 12 months Seres Therapeutics, Inc. (NASDAQ:MCRB) pronounced very strong topline effects from its pivotal section three ECOSPOR III look at evaluating its investigational oral microbiome therapeutic SER-109 for recurrent C. difficile infection. since that announcement Seres' share expense has skyrocketed by way of over 500%. It now has a market cap of pretty much $3 billion without an authorised drug.

*Seres Therapeutics (MCRB) yr to date Chart below

Chartdata via YCharts

other rising microbiome therapeutic biotech agencies include:

a. U.ok. primarily based biotech 4D Pharma PLC (OTCPK:FRPRF) (DDDD.LN) recently launched encouraging phase 1 trial results of its single strand microbiome live biotherapeutic candidate in immuno-oncology. Its candidate MRx0518 is in part 1/2 medical study initially in monotherapy after which in clinical look at combination with Merck's (NYSE:MRK) PD-1 checkpoint inhibitor Keytruda which is displaying promising effects in addressing various melanoma tumors together with breast, NSCLC, and Renal cell Carcinoma amongst others. 4D's method and facts supports Biomica's method although it continues to be to be seen no matter if Biomica's rationally designed 4 strand strategy will generate similar, inferior or superior effects compared to 4D Pharma's single strand method. A Merck subsidiary is partnering with 4D Pharma in this examine. Merck has additionally develop into an investor in 4D.

contemporary nice interim effects have been released via 4D on November 9, 2020 and introduced at SITC. The oral presentation is attainable on 4D Pharma's site and is worthwhile observing. 4D lately announced a merger with a U.S. primarily based SPAC enterprise in order to fitting listed on NASDAQ which it anticipates will turn up in January, 2021.

In 4D's fresh presentation, it indicated that its MRx0518 medical records in immuno-oncology appears to confirm what it saw pre-clinically. in that case, that may additionally even be a favorable signal for Biomica; and

b. Cambridge, Mass. primarily based Vedanta Biosciences (private) which is advancing its pipeline of Microbiome Therapeutic candidates in various signals. Like Biomica, it makes use of a rationally designed multi-strand strategy of up to eleven commensal bacterial traces. A summary of its pipeline and promising medical outcomes can be discovered here.

Biomica's Rationally Designed Multi-Strand are living Microbiome Therapeutics

Biomica Ltd. is advancing its rationally designed multi-strand live microbiome biotherapeutics courses in 3 leading disorder aims including:

(i) immuno-oncology remedy to treat various types of melanoma but at the beginning targeting NSCLC (non-small phone lung melanoma);

(ii) IBD (inflammatory bowel disorder); and

(iii) IBS (irritable bowel syndrome).

additionally, Biomica has a pre-clinical stage small molecule clinical software addressing AMR - Antimicrobial resistance, especially C. difficle toxin-B.

*slide below taken from Biomica's August 10, 2020 corporate presentation

On September 8, 2020 Biomica announced nice pre-medical records for its most superior are living biotherapeutic drug candidate BMC128. When administered in pre-medical animal studies in combination with an Immune Checkpoint Inhibitor "ICI" (PD-1 or PD-L1 and CTLA-four checkpoint inhibitor), it said enormously stronger anti-tumor endeavor and extended animal (mouse) survival.

In my August article on Biomica, there turned into no discussion about BMC128 but simplest about its predecessors, BMC121 and BMC127.

The September 8 press unencumber provided little detail about BMC128 effective pre-scientific consequences however cited,

...In these reviews, Biomica Tested BMC128, which contains four live bacterial traces derived from Biomica’s drug candidates BMC121 and BMC127. medicine with BMC128, each prior to and in mixture with ICI, drastically superior anti-tumor recreation in mice.

These advantageous outcomes complement further fantastic statistics using Biomica’s initial bacterial strain combinations BMC121 and BMC127, which Tested anti-tumor pastime in animal experiences. BMC128 was selected in accordance with extra predictive analysis of the outcomes of Biomica’s stories with BMC121 and BMC 127.

Biomica’s immuno-oncology application is based on the premise that the gut microbiome affects the efficacy of melanoma immunotherapy, principally that of the ICI involving the blockade of PD-1 or PD-L1 and CTLA-four, as suggested in scientific literature.[1] in the current study, BMC128 become administered to mice bearing cancer tumors prior to and all over ICI remedy. BMC128 is a rationally-designed microbial consortium derived from Biomica’s earlier candidates BMC121 and BMC127, which had been recognized and selected through a detailed useful microbiome evaluation the usage of PRISM, a proprietary excessive-decision microbiome evaluation platform powered through Evogene’s MicroBoost AI platform.

Biomica’s existing consequences reveal that treatment with BMC128 ahead of and in mixture with the administration of ICI, tremendously decreased tumor quantity and expanded animal survival compared to ICI remedy on my own. additionally, remedy with BMC128 affected a number of immunological elements, together with particular immune-cells populations normal to be concerned in tumor destruction.[2]

The study suggests that treatment with BMC128 conditions the immune gadget and primes it for an efficient, well-orchestrated anti-tumor response. here's in-line with numerous scientific publications, demonstrating the impact of the intestine microbiome on the response to ICI, and extra in particular a decreased response to ICI in patients with compromised microbiome following treatment with antibiotics.[3] ..."

On October 13 Biomica announced that it had shrunk to start colossal-scale creation of BMC128.

November 18 update: BMC128 established a 50% bigger standard Response fee cutting back Tumor volumes in Pre-medical trials

In Biomica's November 18 conference name, Biomica's CEO Dr. Elran Haber provided further (albeit still incomplete) particulars concerning BMC128 pre-clinical trial effects. according to the November 18th convention call transcript, Dr. Haber stated that:

... the animals were divided into quite a lot of medicine groups, and BMC128 became administered to mice bearing cancer tumors previous to and during ICI remedy.

In September, they announced the fantastic effects of these trials, demonstrating that treatment with BMC128 just before and in combvination twith the adminstration of ICI, enormously decreased tumor quantity and expanded animal survival in comparison to ICI remedy on my own. It looks that Biomica's bacterial consortia adminstered ahead of ICI remedy primes the immune gadget for an effective, smartly orchestrated anti-tumor response, finally leading to the most reduced tumor quantity and finest survivial fee out of all companies. The response to the combination remedy changed into 50% greater in evaluation to the neighborhood that acquired simplest the ICI therapy..."

in the days following the November 18th conference call, I emailed Dr. Haber to make clear what he intended. His response was that the remedy community which got BMC128 in aggregate with an anti-PD1 checkpoint inhibitor ("ICI remedy"), noticed a 50% raise of their normal Response price "ORR" compared to the group treated with an anti-PD1 checkpoint inhibitor by myself.

For those readers unfamiliar with the term common Response expense or ORR within the context of immuno-oncology, it is generally defined as the sum of:

(i) complete responses or CR, where the cancer patient has no detectable proof of a tumor over a detailed time period; and

(ii) partial responses or PR, where the patient shows a decrease in tumor dimension of over 30% over a specified time duration.

ORR does not encompass reliable disorder.

See NCBI article discussing the a number of oncology response definitions discovered right here.

The 50% boost in ORR is probably a big improvement over the pre-clinical statistics which Biomica posted for its previous stage BMC121/BMC127 candidate which showed most effective a 20% greater overall response rate or ORR in tumor response when combined with a PD-1 checkpoint inhibitor ("ICI") in comparison to the group that bought only the PD-1 therapy. they are able to are looking to see all the pre-scientific information for superior knowing.

Of direction, pre-scientific information in mice doesn't always translate into the same stage of clinical effects in people, however the pre-scientific statistics to this point hang promise.

beneath is the ancient BMC121 & BMC127 pre-clinical trial consequences showing a 20% enhance in normal response price in comparison to an anti-PD1 remedy, taken from the Biomica August 2020 slide presentation which I had referenced in my August article on Biomica.

*slide below (ancient BMC121/BMC127) records taken from August 2020 slide.

in the mp;a piece of the November 18 convention name, Haber indicated that he expects Biomica's proof of concept immuno-oncology scientific pilot study with BMC128 to start at a number one clinical facility in Israel in H2 2021 and probably a couple more leading Israeli scientific amenities. meanwhile, Biomica is reviewing a couple of different dosing stages in preclinical fashions.

besides focused on NSCLC (non-small mobilephone lung carcinoma), Biomica is evaluating the effectiveness of BMC128 in RCC (renal telephone carcinoma) and potentially solid tumors comparable to melanoma. Dr. Haber indicated that the proof of concept trial may include patients with quite a few styles of solid tumors.

in accordance with a couple of questions posed to Dr. Haber all through the convention name, he spoke back that:

a. Biomica plans to existing the complete set of facts results from its BMC128 preclinical trials at an incredible European microbiome therapeutics convention in Europe in January, 2021. although Dr. Haber didn't specify the ecu convention, each he and Biomica's VP R&D Dr. Shiri Meshner, Ph.D. are scheduled to communicate on the 5th Annual Microbiome circulation Drug development Europe conference on January 28, 2021. Dr. Haber is scheduled to communicate on the ecu Microbiome Leaders Panel all the way through the morning plenary session on January 28 at 9 a.m. followed via a 12.00 midday (critical European Time) presentation via Biomica's Dr. Shiri Meshner who's scheduled to current on the theme, "From Computational Predictions to Preclinical performance" by which she is to document new high-quality pre-medical results with Biomica's "rationally designed consortia" in Biomica's immune-oncology software, in addition to discussing Biomica's new pipeline software of "utilizing practical microbiome evaluation for targeting stomach hypersensitivity in IBS".

b. the Israeli BMC128 "proof of conception of trial" in 2021 will be akin to a U.S. phase 1/1a clinical study to be carried out in 10 to fifteen cancer sufferers who had been on immunotherapy however where the immunotherapy had failed. Biomica will treat them within the preliminary look at with a mix of BMC128 and an ICI;

c. Biomica plans to use the records acquired from the Israeli BMC128 "proof of idea" trial in discussions that it's planning to have with the U.S. FDA to file an IND to provoke BMC128 medical experiences within the U.S. in 2022 (most likely for a part 2 examine, assuming the Israeli "proof of idea" pilot analyze is a hit);

d. in explaining why he believed that Biomica's method with BMC128 of advancing a rationally designed (4 strand) live bio-therapeutic would do improved in an immuno-therapy surroundings than a single strand approach [such as competitor 4D Pharma's single strand approach], is the ability to supply a patient with a centered useful mixture and to target the melanoma tumor with a "number of modes of motion" thereby enhancing the effectiveness of this rationally designed four strand strategy.

Of path, except BMC128 scientific records ultimately becomes available they won't know the reply to the query as to whether Biomica's rationally designed multi-strand (4 strand) live biotherapeutic is extra beneficial than the one strand strategy being superior by means of as a minimum one competitor.

2. Lavie Bio Ltd.

72% owned subsidiary Lavie Bio Ltd. is focused on establishing,

i) bio-stimulants - ag-biologicals for crop enhancement, directly impacting crop yield or abiotic stress tolerance; and

ii) bio-pesticides - ag-biologicals for crop protection, addressing biotic stresses reminiscent of bugs, ailments and weeds.

final August 2019, Corteva (CTVA) (a $27 billion market cap enterprise spun off from DowDuPont), made a right away funding in Lavie Bio price $27.5 million in return for a 28% hobby in Lavie Bio and appointed considered one of its senior americans to Lavie Bio's board of directors. The Corteva transaction gave Lavie Bio a valuation of about $one hundred million returned in August 2019. because then Lavie Bio has made additional advancements and in my opinion more effective. Lavie Bio become the focus on my 2d article during this 4-half Evogene series.

For extra assistance about Lavie Bio and its pipeline please discuss with Lavie Bio's web site domestic - Lavie Bio in addition to my August 24, 2020 article/

*slide beneath taken from Lavie Bio's August 20, 2020 company presentation

Lavie Bio is at the forefront of a eco-friendly revolution in agriculture because the industry shifts from the use of chemical-based mostly (poisonous) inputs to greater natural, non-poisonous microbial-based ag-biologicals. This specific eco-friendly revolution (are living ag-biological microbial solutions) has only been feasible due to the contemporary tendencies in computational predictive biology, genomics, massive facts (big really expert databases), and AI.

The demand for these types of novel ag-biologicals is being pushed with the aid of the customer who's increasingly worrying non-poisonous (or at least minimally poisonous) and greater herbal pesticides, herbicides, biostimulants and other agricultural product inputs. Ag-biologicals (including novel main-side reside microbial biostimulants, pesticides, herbicides, and so forth.) are a novel solution developed by utilizing essentially the most subtle technology, biology and genomics.

Lavie Bio's most advanced product is LAV-211 which is a form of biostimulant seed remedy the use of microbes. Biostimulants aren't as regulated as biopesticides, so the building time to commercialization is shortened by way of a number of years.

As described in more detail in my August twenty fourth article, the trial statistics reveal that LAV-211 improves spring wheat yield with the aid of an average of 6% which translates into $20 to $50 extra revenue for a farmer per acre.

all through the November 18th query and reply component to the convention call, Evogene's CEO indicated that Lavie Bio is at present accumulating the outcomes of container trials for LAV211 in North Dakota and Montana for its spring wheat program, and that it is planning pre-commercial actions for LAV211 in 2021 to begin in 2021 so they can consist of distributing LAV211 to "big farmers" for business field trials. it's predicted that LAV211 may be at a industrial stage and generating revenues in 2022.

while the ultimate pricing for LAV211 has no longer yet been decided, comparing the pricing of competitive products, the fee of LAV211 will likely be within the latitude of $6.00 to $eight.00 per acre or most likely priced larger as a premium product.

Assuming Lavie Bio (or its companions or agents) can attain a 20% market share of the primary focal point market's 25 million acres, that works out to be revenue of $30,000,000 to $forty,000,000 per annum (based mostly upon 5 million acres calculated at $6.00 to $eight.00 per acre) for the check market of "spring wheat".

"winter Wheat" is a different potential marketplace for LAV211. iciness wheat is planted in or about November, before the wintry weather snow. based on Lavie Bio's CEO, the LAV211 market for iciness wheat is probably 5 to 10 times higher than spring wheat. The building testing and timing of LAV211 for "iciness wheat" has no longer yet been released.

LAV211 can additionally doubtless be elevated into different agricultural plants akin to oats, which is a profitable market now on account of the oat milk market.

I prior to now estimated that LAV211 has the advantage to generate annual revenues within the $100 million latitude for "spring wheat" and different items with industrial earnings within the spring wheat market beginning in 2022. The market for LAV211 may be extended additional to other items however no extra details have yet been offered.

LAV311 and LAV312 - Advances into "development Stage 2"

Lavie Bio's second most superior products are its two leading microbiome based mostly bio-fungicide candidates LAV311 and LAV312, which goal bunch rot illnesses. this is a potentially lucrative market. in response to Lavie Bioi the market for LAV311/LAV312is estimated to be $200 million per yr for the medication of fruit rot of grapes brought about by means of botrytis cinerea but the market generally is a numerous of that figure if utilized as a medicine for a much wider variety of vegatables and fruits.

On October twenty ninth, 2020 Lavie Bio introduced that its experimental vineyard trials with LAV311 and LAV312 generated very positive box trial outcomes which has superior LAV311 and LAV312 as development Stage 1 candidates into “building Stage 2” candidates. This building is an important step against acquiring regulatory approval in order to launching LAV311 and LAV312 commercially in 2024 and increases their cost.

... These winery trials, performed in goal places in Europe and the U.S., resulted in significantly more desirable efficacy and consistency than present comparable commercial biological benchmarks, and aggressive to industrial chemical benchmarks, each tested as part of those trials. The positive consequences will assist Lavie Bio’s latest plan to launch its first bio-fungicide product for controlling bunch rots for use in fruit and vegetables in 2024.

instance of remedy with LAV312 towards Botrytis Cinerea in vines – untreated manage vs treated vines

damage from crop sickness is rising, with present efforts mostly reckoning on chemical crop insurance policy, with fungicide chemicals accounting for $18.7B in annual expenditure in 2019.[2] on account of increasing ailment resistance to current chemical substances and demand for extra sustainability practices, there's a well-diagnosed and unexpectedly becoming want for new and positive solutions, with ag-biologicals being an important device in addressing this challenge.

Bunch rots are devastating illnesses and the estimated annual expenditure on crop coverage with existing chemical solutions is within the $100s of thousands and thousands[3]. New and efficacious organic items can also be integrated into the farmer’s current IPM (built-in Pest management) practices as a result using both productive and sustainable practices, while reducing the emergence of pest resistance to present crop protection solutions.


These trials showed that vineyards treated with each and every of LAV311 and LAV312 established 60-70% discount in crop harm due to bunch rots in assessment to the control. ..."

In a cellphone conversation with Lavie Bio's CEO Ido Dor on November three (to focus on the trial outcomes announced in the October twenty ninth press release), he defined that LAV311 and LAV312 have a novel mode of action (microbiome pushed) which have proven equivalent or sophisticated degrees of efficacy compared to chemical pesticides but devoid of the toxicity of existing chemical pesticides.

here's probably a multi-billion dollar market. LAV311 and LAV312 may well be used as a bio-fungicide not best in grape vineyards however also for different fruits, vegetables, and plant plants starting from grapes, tomatoes to cannabis.

Evogene (Lavie Bio) has indicated that it anticipates that LAV311 and LAV312 could be approved and launched for business earnings within the U.S. in 2024. if so, that might imply that Lavie Bio may be submitting for regulatory approval of LAV311 and LAV312 within the U.S. (probably within the states with tremendous markets such as Oregon, California, and many others.) by means of mid-2022 as the approval technique usually takes 20 to 24 months from the time of filing.

three. Ag Plenus Ltd.

Evogene's wholly-owned subsidiary AgPlenus Ltd. designs and develops novel mode of motion non-poisonous herbicides, pesticides, fungicides, and crop enhancers to address an urgent need for such new products.

AgPlenus is becoming identified as a pacesetter in computational predictive biology to establish and boost these chemical compounds with novel modes of action. it's partnering with probably the most main agriculture businesses on the planet together with Corteva, BASF, and Israel-based mostly ICL neighborhood, one of the crucial greatest fertilizer corporations in the world.

*slide below taken from AgPlenus' August 2020 company presentation

many of the most standard herbicides have been banned in quite a lot of constituents of the area on account of toxicity, environmental, and toxins issues. in addition, these earlier technology herbicides have all started to turn into weed resistant. This has become a worldwide problem and created a giant demand for subsequent-generation herbicides with new modes of motion (i.e. non-poisonous) to assist farmers control all weeds and raise crop yields.

As there has now not been a novel mode of action authorised herbicide in the market for very nearly 30 years, there's enormous business value in bringing one or more into the market.

AgPlenus' activities center of attention on the building of novel herbicides, with a robust focus on novel modes-of-action, and on novel pesticides, focusing on new websites-of-motion. AgPlenus is also lively in fungicides and crop enhancers.

*slide under taken from AgPlenus' August 20, 2020 presentation

AgPlenus's HERB32 - Novel Mode of motion Herbicide Expects to be a "Lead" next month

AgPlenus' most advanced novel mode of action herbicide is HERB32 and a potential answer to a toxic herbicide corresponding to Bayer's (Monsanto's) flagship herbicide "RoundUp".

all through the November 18th conference call, Evogene's CEO Ofer Haviv indicated that AgPlenus turned into now collecting information from a box scan performed through third events in the U.S. testing HERB32, and expected to have the effects and records from the trial in the subsequent 2 weeks, and if fantastic, will announce HERB32 as a "Lead".

*slide below taken from AgPlenus' July 2020 corporate presentation

Having its most superior herbicide candidate HERB32 acquire "Lead" popularity is an important milestone for AgPlenus. A "Lead" has big business cost in itself and may be licensed out in standard offers in which multiple tens of millions of bucks are paid upfront, extra milestone funds can be paid, and a single-digit royalty generated on commercial income generated via the Licensee.

despite the fact, advancing HERB32 from a "Lead" to an "Optimized Lead", which is anticipated to take about 18 months, will materially enhance the value of HERB32 or as CEO Ofer Haviv cited on the November 18th convention call, "here's where the huge, big cash is".

As indicated in Evogene's November 18th press free up a part of the $22 million in cash these days raised through Evogene is anticipated to be used to advance HERB32 from a "Lead" to an "Optimized Lead".

as soon as HERB32 attains "Lead" repute (and certainly as an "Optimized Lead"), it becomes a very useful acquisition target for colossal ag organizations corresponding to Bayer, BASF and Corteva.

in line with AgPlenus, the price of a commercially ready "novel mode of motion" herbicide is huge as it might generate peak annual earnings of U.S. $750 million to $1.5 billion.

apart from HERB32, AgPlenus has greater than 10 in its pipeline that are already "Hits" and have become "Leads" in the following couple of years

each new novel herbicide, insecticide, or fungicide molecule has an identical competencies if it reaches a "Lead" or "Optimized Lead" stage respectively.

*slide below taken from AgPlenus' August 2020 corporate presentation.

four. Canonic Ltd.

Evogene's entirely-owned subsidiary Canonic Ltd. has Israel's greatest hashish R&D facility, is fully licensed, and has a state of the paintings 22,000 rectangular foot greenhouse, tissue culture and molecular labs. It has additionally developed proprietary databases to "breed genetically strong forms for enhanced therapeutic effects and better yield." For more advice, see Canonic's September 2020 corporate presentation as well as my September 23, 2020 article on Canonic.

On November eleven, 2020, Evogene introduced that Canonic had received licensing popularity of the propagation of scientific hashish from the Israeli scientific cannabis company,

... This approval will allow Canonic to proceed with the execution of its commercialization plan of clinical cannabis products.

Canonic’s propagation farm, which became established during 2020 and is now absolutely operational, is designed for the propagation of cannabis seedlings from its R&D greenhouses. These seedlings are anticipated to be additional cultivated by means of third-party certified scientific hashish growers. The company intends to set up a value chain from genomics to the conclusion-product, with definite elements of the value chain outsourced to sub-contractors. The enterprise intends to convey its first batch of seedlings to such cultivation farms all through 2021. ..."

beginning with plant genetics, Canonic is establishing cannabis types that handle the scientific hashish business concerns relating to "genetic balance, compound yield, and active compounds". It plans to start selling its medical hashish items, beginning in Israel (after which Europe) in 2022. The North American market could be addressed in future years.

Canonic has two product households below development which it refers to as:

1. MetaYield - hashish flora and seeds under building which stabilizes and raises total active compounds per plant, as well as enhance vegetation with selected features to increase compounds per planted area (eg. dwarf plant life, plant life which flower past and that could boost the number of crops planted per 12 months);

2. genuine - establishing cannabis flora with reliable, particular energetic compounds (eg. cannabinoids similar to CBG, CBC, and so on). Canonic is additionally constructing these flowers with these compounds which address selected scientific needs (eg. ache and irritation) along with pre-medical and scientific scientific reports that it's conducting with definite scientific institutions.

Canonic Anticipates First industrial Launch in at least One MetaYield variety in 2022

Canonic's first commercial types could be at least one "MetaYield" variety which Canonic has no longer supply particulars other than to propose that the primary market will focal point on the T20/C5 (20% THC, 5% CPD) market. at present, groups marketing clinical cannabis with T20/C5 target are providing products that may additionally contain energetic elements that are 20% bigger or lessen than distinct on the label.

Canonic plans on cutting back that variability tremendously. possibly, particulars might be launched over the next 12 months as pre-commercial actions accelerate.

The initial business forms of Canonic's first two MetaYield hashish plant varieties are also anticipated to generate plenty better yields per acre and plenty higher degrees of energetic compounds per plant.

The initial industrial market for Canonic's first two MetaYield forms could be Israel which has a surprisingly big clinical hashish market for its 9 million inhabitants, with an estimated market of approximately $a hundred and seventy million in 2022. Canonic plans to extend instantly into the ecu market in 2022 which, while fragmented via nation, is a numerous of the Israeli market. Canonic plans to attain the U.S. market in 2023 which is a multi-billion dollar market.

Canonic's exact+ Product family unit (clinical Indication center of attention)

specific Product #1: focused on irritation: Canonic's first expected precise product will address irritation. Pre-medical reviews are presently underway with the Hadassah clinical Centre.

If the pre-clinical facts gathered from these reports is favorable, it could be a significant catalyst for Canonic. If all goes smartly, Canonic believes it'll begin business income for its clinical hashish products to treat inflammation in 2023, beginning in Israel, then Europe and North the united states. Canonic estimates that the Israeli annual market measurement for irritation alone is within the $70 million range.

genuine Product #2: focused on ache: Canonic's 2d specific medical target indication is for the treatment of ache. different signs will follow sooner or later.

Canonic expects to have its Precision medical hashish product #2 for the medicine of ache commercially available to be launched in Israel, and then Europe and the U.S. in 2023. Canonic estimates that the market size in Israel on my own for this product in 2023 may be in the $217 million range. The medical hashish markets for the medicine of pain in Europe and the U.S. are predicted to be in the billions.

How will Evogene unlock Shareholder price?

Evogene is a greater complicated business to be mindful, with subsidiaries in different sectors and loads of relocating constituents. The mum or dad enterprise and each subsidiary enterprise is valued the use of diverse metrics and followed by using distinct analysts and various kinds of investors. It can also be intricate for any single analyst or investor to comply with or bear in mind Evogene's price advent devoid of a big quantity of effort.

as an instance, the valuation of a microbiome therapeutic biotech company such as Biomica uses very different metrics, and is customarily valued at a plenty bigger distinctive of its skills, than an ag-chemical or ag-organic business similar to Lavie Bio or Ag Plenus. The same can be talked about of a medical cannabis enterprise corresponding to Canonic which is also subject to the valuation and demand trends within the cannabis sector.

in my view Evogene will trade at a reduction on account of its advanced company structure in growing varied diverse subsidiaries in different sectors.

The glaring question then is how and when will Evogene release shareholder value?

i was hence joyful to hear CEO Ofer Haviv begin to handle that situation within the November 18 salary call that,

... these capital raises carry us nearer to alternatives to free up the price of their subsidiaries. achieving the crucial developmental milestones, they outline in their enterprise presentation, could put their subsidiaries in a stunning situtation to capitalize on their achievements, akin to within the kind of investment of a strategic or financial partner, M&A or an IPO."

Evogene's subsidiaries are indeed maturing to a level where they seem capable in the subsequent couple of years to "capitalize on their achievements".

Evogene has already signaled that it has ample funding to take Biomica via to its Israeli "proof of thought" pilot analyze in BMC128 (immuno-oncology). for my part, assuming that Biomica's proof of theory records are fine, as Biomica starts off coaching to gain an IND from the U.S. FDA would be a fantastic time to lift money for its own IPO, thereby starting a technique of unlocking Biomica's value for Evogene's shareholders. I see the timing of this IPO technique for Biomica as being in late 2021 or early 2022.

With admire to Lavie Bio and AgPlenus, assuming all goes well, each are expecting gigantic milestones in 2022 as Lavie Bio starts off industrial revenue in LAV211 and AgPlenus' HERB232 herbicide attains "optimized lead" popularity. I don't agree with that an independent IPO is essential for both Lavie Bio or AgPlenus however 2022 might see a 12 months where the corporations are either bought out or huge licensing transactions take location.

as far as Canonic (medical hashish) is concerned, it has the same issue as Biomica in that its valuation is buried within Evogene and not understood by means of investors concentrated on Ag chemical substances, Ag biologicals or microbiome therapeutics. with a view to unencumber Canonic's value, I accept as true with it must be spun out both via its personal IPO or via an M&A transaction.

Canonic anticipates commercial sales in 2022 and that can be an appropriate time for such an M&A or IPO transaction as neatly.

certainly, one or more of the subsidiaries are getting nearer to a stage all the way through the subsequent couple of years the place they might be ripe for an IPO (eg. Biomica) or being purchased out (akin to Corteva, Ag Plenus, or Canonic) as they achieve vital levels of company fulfillment. the sort of experience would be a huge catalyst for Evogene's share fee.

In my analysis, I have not yet attributed a lot value to the Computational Predictive Biology platform developed by using Evogene, doubtless because its value is presumably subsumed in the course of the valuation of its subsidiaries or extra realistically as a result of I truly don't know the way to cost it independently (despite the fact I have canvassed this question with many individuals a good deal smarter than me and no person looks to have a definitive reply). despite the fact, i'm very mindful that the impartial cost of the CPB platform may certainly be giant. If Evogene proves that its CPB platform is capable of successfully creating distinct success reviews in constructing various lifestyles science items it'll actually show out its large price. At some aspect sooner or later, that value can be recognized.

summary of Upcoming Catalysts/Milestones 1. ninety% owned Biomica

January 28, 2021 - details of fine pre-scientific consequences with rationally designed 4 strand consortia BMC128 in immuno-oncology being mentioned at the 5th Annual Microbiome Europe conference 5th Microbiome flow - Drug development Summit Europe 2021

H1 2021 - complete pre-scientific reports for BMC128 and filing of materials with Israeli regulators to begin "proof of thought" human trials in monotherapy and in combination with an immuno-checkpoint inhibitor (Immune Checkpoint Inhibitor "ICI" (PD-1 or PD-L1 and CTLA-four)

H2 2021 - start "proof of conception" pilot human clinical trials with BMC128 in immuno-remedy in one or greater important medical facilities in Israel.

H1 2021 (my estimate) - Preclinical effects released from BMC321 / BMC322 in medicine of IBD in studies currently being carried out at the school of North Carolina on the lab of Professor Balfour Sartor.

H1 2021 - Discovery phase completed and initiation of pre-clinical reviews with regard to advancing IBS.

H1 2022 (my estimate) - scientific results from "proof of thought" BMC128 trial in immuno-oncology.

H1 2022 (my estimate)- submitting of IND with the FDA in U.S. for BMC 128 (phase 1b/part 2) medical trial in immuno-oncology.

Late 2021/ H1 2022 (my hypothesis) - Biomica launches an IPO on NASDAQ raising cash in anticipation of beginning US BMC128 clinical trials and the building of its microbiome therapeutic pipeline.

2. seventy two% owned Lavie Bio - Ag biologicals

2021 - LAV211 (for treatment of spring wheat) advances into the pre-industrial construction stage in U.S. in anticipation of a 2022 business launch.

2021/2022 (my estimate) - expertise milestone payments from Corteva as Lavie Bio's biostimulant candidates for corn advances into development levels.

Q1 2022 - First industrial sales in LAV211 for medicine of "spring wheat" in initial 25 million-acre spring wheat North Dakota/Western Canada market

H2 2022 - Biopesticide LAV311/LAV312 (currently superior into building stage 2) -regulatory filing in various U.S. states.

2022 to 2024 - growth of LAV211 earnings for "spring wheat" into better territories in addition to skills growth into other items (2022 to 2024) (market expertise >$one hundred million).

2023 - Biopesticide LAV311/312 (fruit rot of grapes, and other fruits and vegetables) pre-business stage in 2023

2024 -LAV311 / LAV312 first commercial sales (2024) (skills market >$200 million to greater than $1 billion).

2025 - Biopesticide LAV321/LAV322 (Downey Mildew) anticipated commercial earnings in 2025 (talents market >$350 million).

3. Ag Plenus - Ag chemical compounds

December 2020 - Novel mode of motion herbicide HERB32 turns into a "Lead".

2021 - H2 2022- HERB32 undergoes extra trials and optimization reviews and turns into an "Optimized Lead" in H2 2022.

H2 2022 - licensing deal for HERB32 (as an "optimized Lead") with one or extra primary agriculture enterprise.

2021 to 2024 - quite a few other pipeline herbicides, pesticides and insecticides in Ag Plenus' pipeline acquire "Lead" and "Optimized Lead" reputation, with competencies licensing offers.

4. Canonic (clinical hashish)

2021 - 2022 - unlock of trial effects for its MetaYield and genuine products, including the free up of records in 2021 from its pre-clinical scientific stories.

2021/2022- Pre-commercial actions in 2021 for its MetaYield products in anticipation of business launch in 2022.

Evogene investment Thesis

With a market cap of approximately $105 million (including cash of approximately $50 million and no debt), on a sum of elements foundation, Evogene is undervalued.

Evogene's computational predictive biology platform is developing monstrous price via its subsidiaries so that you can hopefully be recognized and unlocked in subsequent couple of years. currently, Evogene has been attracting extra funding from subtle buyers akin to ARK invest (through its genomics ETF fund (ARKG)) which is now Evogene's greatest shareholder, possessing approximately 12% of the enterprise.

With dissimilar upcoming catalysts and milestones, each and every of its 4 leading subsidiaries is making huge progress, and materially expanding shareholder price.

With many colossal upcoming milestones and catalysts amongst its four main subsidiaries, if all goes neatly, Evogene may handsomely reward traders within the next few years.

right through its exact November 18th salary name Evogene's CEO articulated his strategies about Evogene's plans to liberate shareholder cost via a strategic or economic companion, M&A or an IPO of 1 or extra of its subsidiaries. with a bit of luck, these plans will develop into clearer in 2021.

investment dangers

however the talents enormous upside, Evogene is still a relatively early stage ag-tech/ biotech business with out a material current or predictable future revenues, correct for investors with a excessive-possibility tolerance. An funding in Evogene may outcomes in the loss of some or your entire investment.

before making an funding in Evogene, you'll want to do your personal due diligence and procure professional counsel to investigate whether it is a suitable funding for you and the sizing of such an investment.

funding hazards include, but aren't confined to, the probability of developmental trial disasters, underwhelming clinical or other test results, competition, IP infringements, patent challenges, regulatory considerations, loss of key personnel, share dilution, difficulty in elevating new cash either at the mother or father or subsidiary stage in the future, the failure of management to execute upon its business plan including advertising and marketing, difficulty in buying companions or getting into licensing offers and universal market dangers.

Evogene's business mannequin is frequently dependent on collaborating or partnering its assets at a number of tiers of building. there is a possibility that these collaborations or partnerships may additionally now not materialize or may additionally now not be as profitable or as well timed as hoped for or expected.

For further details of the knowledge risks involved, see the risk elements set out in the enterprise's most fresh public SEC filings together with its form 20F filed on July 27, 2020.

Disclosure: i am/we are long EVGN. I wrote this article myself, and it expresses my own opinions. i am not receiving compensation for it (aside from from in the hunt for Alpha). I have no company relationship with any business whose stock is outlined listed here.

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